I just tested
AnyDVD with Cold Feet Series 2 Episode 1 length 48 minutes 46 seconds File size 2,426,294,272 bytes using a NEC DV-5800B DVD ROM
Total time to encode with
DVD2one was 30.14 using AnyDVD (i.e I encoded straight from the original DVD).
Decryption with DVD Decrypter took 5.42 minutes and encoding the resulting file with DVD2one took 8.24 minutes.
Conclusion: AnyDVD is slow but might be useful if your looking to do backups with minimal user intervention - especially if you have the option to burn with DVD2one. Maybe DVDBot would be a better solution - I haven't tried it yet.
As for the region code removal I had to reboot each time I wanted to change regions.