Clone is compatible with just about everything, even Linux & BeOS.

The issue with all of this is bus-mastering, VIA, ALI & AMD do not do it well; Intel is a little better but Microsoft is best. From UDMA33 onwards it has become an issue because bus mastering means that a capable device wants to 'master the bus' or have sole control of it, to do what it needs to do; Chip Chapin's website has a good primer on this topic. You can safely load all VIA drivers except the busmaster driver - see the VIA website for what's what. The best way to go is:

Win95 - cannot busmaster...linked to the pre-BX chipset issue.

Win98(SE) - use the drivers off the CD i.e. boot up and let Windows search for drivers when it detects the new device (MoBo).

Win ME - same (do people still use this?)

Win2K - same; but note that there are separate 'out-of-the-box' UDMA issues with Win2K; hot fixes from MS & XP Setup are available.

Win XP - use the native drivers i.e. do not load the VIA 4in1 over the top of a shiny new XP system.

Under no circumstances should you use the Intel Ultra DMA Storage Driver (the one that's about 2-3 Meg), it takes over your system and cannot be uninstalled.

Do this without using the CD-ROM with the MoBo or any downloaded 4in1 and you're off to a good start. Selectively install the VIA drivers as you wish.

NB: if you already have VIA, ALI etc drivers installed, Windows may kick these in on reboot - uninstall older drivers first. Latest 4in1s have no uninstall so you have to roll back to 4.28 (see VIA website) and uninstall from there.