Something MUST be different from before...

First Check your ASPI with the Nero Infotool or this adaptec util (found here) [If OK Proceed, if not use the repair util]

Secondly Check you have the latest firmware [If up-to-date and still getting error proceed]

Thirdly Try a different piece of software [If works proceed to next step]

Fourthly Reinstall CloneCD

(If all steps unsuccessful then get back to me)