Initially I had tried using a Dell D600 docked, with it's DVD/CDRW combo and CD Clone 5.3.0.1.
The Problem Medium Error banner appeared and stopped the process.

So, I attached a vintage ACER USB 8824 cdrw drive.
I used the Dell cdrw drive to read the production Renegade disk, and the ACER drive to write the backup copy.

This configuration did work successfully, and the backup works on my original Compaq Desktop. (Which is the whole reason behind the effort )
My kids play renegade on that desktop, and kids being kids, CDs tend to pile up unprotected. EA games typically require you to put in a serial CD to get the game to work.

My next test will involve upgrading CD Clone to 5.3.0.1 from 5.1.8.1 on the Compaq machine and test there.

Thanks,
Derek